Synthesis of Tryptophan Metabolites by Biomimetic Reactions
نویسندگان
چکیده
منابع مشابه
Neurotoxicity of tryptophan metabolites.
The metabolism of tryptophan by the kynurenine pathway leads to the production of several neurotoxic compounds, some of which have been associated with neurological disorders. Recent investigation of some relevant compounds in this pathway has provided further evidence of their neurotoxicity.
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The kynurenine pathway generates multiple tryptophan metabolites called collectively kynurenines and leads to formation of the enzyme cofactor nicotinamide adenine dinucleotide. The first step in this pathway is tryptophan degradation, initiated by the rate-limiting enzymes indoleamine 2,3-dioxygenase, or tryptophan 2,3-dioxygenase, depending on the tissue. The balanced kynurenine metabolism, w...
متن کاملQuinolinate-induced cortical cholinergic damage: modulation by tryptophan metabolites.
Certain products of tryptophan metabolism interact with excitatory amino acid receptors to produce or protect against excitotoxicity. In this study, the action of several tryptophan metabolites, yielded by the kynurenine pathway, on cortical cholinergic toxicity was evaluated following focal injection into the rat nucleus basalis magnocellularis (nbM). Metabolites were injected singly or in com...
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Tramadol has recently been isolated from the roots and bark of Nauclea latifolia. A plausible biosynthetic pathway has been proposed and the product-precursor relationship has been probed by (13)C position-specific isotope analysis. By further exploring this pathway, we demonstrate that a key step of the proposed pathway can be achieved using mild conditions that mimic in vivo catalysis.
متن کاملAsymmetric aldol reactions catalyzed by tryptophan in water.
Tryptophan was shown to be able to catalyze direct aldol reactions between various cyclic ketones and aromatic aldehydes in water with high enantioselectivity.
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1986
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.106.11_964